Cancer in Women

Aleyamma Mathew

Abstract


Cancer is emerging as a public health problem among an array of non-communicable diseases. The common cancers in women are breast, cervix uteri, colo-rectum, ovary, corpus uteri, lung and oral cavity. Breast cancer (BC) is the common cancer (20-30% of all cancers in women) and the leading cause of cancer death in women worldwide. About half of the BCs and 60% of the deaths are estimated to occur in economically developing countries. In most of the registries in India, BC is the commonest cancer with the highest incidence of nearly 50 per 100,000 women in Trivandrum. Half of this cancer is reported in <50 years of age and it exercises adverse influence on the productive role of women in the society. The factors that contribute to the international variation in BC incidence rates are largely due to the differences in reproductive and hormonal factors and the availability of early detection services.

Gynecological cancers account 15-30% of all cancers in women. Cervix uteri cancer (CC) is the 3rd most common cancer affecting women worldwide, the most common cancer among women in several less developed countries and 2nd common cancer in India. During last few decades, this cancer incidence has been decreased in India. Significant declines in CC are likely due to changes in marriage and family planning, supported by underlying improvements in education and socioeconomic status. In spite of decreasing incidence of this cancer, gynecologic cancers have increased in India. Among these, ovary and corpus uteri cancers are the major contributors. Ovarian cancer (OC) has emerged as one of the common malignancies affecting women in India and is the 5th common cancer in India (4th common in Trivandrum). A steady increase has been observed in OC incidence in several registries including Trivandrum. More than 50% of women with OCareunder the age of 50 years. The risk of it increases in 

women who have ovulated more over their lifetime. This includes those who begin ovulation at a younger age or reach menopause at an older age. Other risk factors include hormone therapy after menopause, fertility medication and obesity. Factors that decrease risk include hormonal birth control, tubal ligation, and breast feeding. Efforts are to be made to detect ovarian cancer at an early stage by educating population about the risk factors. Corpus uteri cancers (CUC) are most common in western countries but are becoming more common in Asia. In India, the highest CUC incidence rates are observed in Trivandrum and its incidence has been increasing. Presently, it is the 5th common cancer among women in Trivandrum, 75% of women are over the age of 50 years. The risk factors of CUC include obesity, diabetes mellitus, BC, use of tamoxifen, never having had a child, late menopause and high levels of estrogen.

Colo-rectal cancer (CRC) is the 2nd most common cancer in women world-wide. The burden of CRC has risen rapidly in some economically developed Asian countries like Japan, South Korea and Singapore. In India, the highest CRC incidence rates are observed in Trivandrum and its incidence has been increasing. Presently, it is the 5th common cancer among women in Trivandrum. The major factors include certain dietary practices and family history of cancer. Individuals with a family history of colon cancer, especially if more than one relative has had the disease, are at increased risk of CRC. Other common cancers in women are tobacco-related cancers such as oral cavity (lip, tongue and mouth) and lung. Declining trends in mouth cancer has been reported in India.

Results on the burden, trends in incidence & mortality, risk factors of breast, cervix uteri, ovary and corpus uteri colo-rectal, lung and oral cavity cancers will be presented.

Keywords : Cancer in women, breast cancer, cervix uteri cancer, corpus uteri cancer, ovarian cancer, colo-rectal cancer, gynecological cancer, hormone therapy, menopause, oral cavity cancer.


Keywords


Cancer in women, breast cancer, cervix uteri cancer, corpus uteri cancer, ovarian cancer, colo-rectal cancer, gynecological cancer, hormone therapy, menopause, oral cavity cancer.

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References


Ferlay J, Soerjomataram I, Ervik M, et al. (2014). GLOBOCAN 2012 v 1 . 0 , Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11. Lyon, France.

NCRP (National Cancer Registry Programme) (2016). Three year report of the population based cancer registries 2012-2014: Report of 27 PBCRs: Indian Council of Medical Research, Bangalore, India.

Jemal A, Center MM, DeSantis C, Ward EM (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19:1893–1907.

Dhillon PK, Yeole BB, Dikshit R, et al. (2011). Trends in breast, ovarian and cervical cancer incidence in Mumbai, India over a 30-year period, 1976–2005: an age-period- cohort analysis. Br J Cancer 105

:723-730.

Lima CA, Rangel MR, Macedo- Lima M, da Silva AM (2012). Time trends in breast cancer incidence and m o r t a l i t y i n a m i d - s i z e d northeastern Brazilian city. BMC Public Health 12: 883.

Merlo DF, Ceppi M, Filiberti R, et al. (2012). Breast cancer incidence trends in European women aged 20- 39 years at diagnosis. Breast Cancer Res Treat 134 :363-370.

Jia M, Zheng R, Zhang S, et al. (2015). Female breast cancer incidence and mortality in 2011, China. J Thorac Dis 7: 1221-1226.

Li C, Yu C, Wang P (2015). An age- period-cohort analysis of female breast cancer mortality from 1990- 2009 in China. Int J Equity Health 14:76.

Sloan FA, Gelband H, editors ( 2 0 0 7 ) . C a n c e r C o n t r o l Opportunities in Low- and Middle- Income Countries. Washington, DC, USA: Institute of Medicine of the National Academies.

Porter P (2008). “Westernizing” women's risks? Breast cancer in lower-income countries. NEJM 358 : 213–216.

U n g e r - S a l d a ñ a K ( 2 0 1 4 ) . Challenges to the early diagnosis and treatment of breast cancer in developing countries. World J Clin Onco l10: 465–477.

Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A (2009). Changing trends in incidence of ovarian cancer - the Indian scenario. Asian Pacific J Cancer Prev 10: 1025-1030.

Dikshit RP, Yeole BB, Nagrani R, et al. (2012). Increase in breast cancer incidence among older women in Mumbai: 30 - year t rends and predictions to 2025 . Cancer Epidemiol 36: e215-e220.

Mathew A, George PS, Arjunan A, et al. (2016). Temporal Trends and Future Prediction of Breast Cancer Incidence across Age Groups in Trivandrum, South India. APJCP 17: 2895-2899.

Ghiasvand R, Adami H-O, Harirchi I, et al. (2014). Higher incidence of premenopausal breast cancer in less developed countries; myth or truth? BMC Cancer 14: 343.

Mathew A, Gajalakshmi V, Rajan B, e t a l . ( 2 0 0 8 ) . P a t t e r n o f anthropometric factors among urban and rural women in south India and the r i sk of breast cancer: a multicentric case-control study. Br J Cancer 99: 207-213.

Mathew A, Gajalakshmi V, Rajan B, et al. (2009). Physical activity level among urban and rural women in south India and the risk of breast cancer: a case-control study. Euro J Cancer Prev 18: 368-376.

Gajalakshmi V, Mathew A, Brennan P, et al. (2009). Breastfeeding and breast cancer risk in India: a multicenter case-control study. Int J Cancer 125: 662-665.

Rose DP, Vona-Davis L (2010). Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 66: 33–38.

Hemminki K, Försti A, Sundquist J, Mousavi S (2011). Preventable breast cancer is postmenopausal. Breast Cancer Res Treat 125: 163–167.

Amadou A, Ferrari P, Muwonge R, et al. (2013). Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose- response meta-analysis. Obes Rev 14: 665-678.

Assi HA, Khoury KE, Dbouk H, et al. (2013). Epidemiology and prognosis of breast cancer in young women. J Thorac Dis 5: S2–S8.

Mathew A, Rajan B, Pandey M (2004). Do younger women with n o n - m e t a s t a t i c a n d n o n - inflammatory breast carcinoma have poor prognosis? World J Surg Oncol 2: 2.

Anders CK, Johnson R, Litton J, et al. (2009). Breast Cancer before Age 40 Years. Semin Oncol 36: 237–249.

Keramatinia A, Mousavi-Jarrahi S, Hiteh M, Mosavi-Jarrahi A (2014). Trends in Incidence of Breast Cancer among women under 40 in Asia. Asian Pac J Cancer Prev 15: 1387-1390.

Forouzanfar MH, Foreman KJ, Delossantos AM, et al. (2011). The accuracy of cancer mortality statistics based on death certificates in the United States. Cancer Epidemiol 35(2):126-131.

Katanoda K, Matsuda T, Matsuda A, et al. (2013). An updated report of the trends in cancer incidence and mortality in Japan. Jpn J Clin Oncol 43: 492-507.

Mathew A, George PS (2009). Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix

–worldwide. Asian Pacific J Cancer Prev 10 (4): 645-650.

Morris CR, Epstein J, Nassere K, et al. (2010). Trends in Cancer Incidence, Mortality, Risk Factors, and Health Behaviors in California. Sacramento, CA: California Department of Public Health, Cancer Surveillance Section.

Murthy NS, Chaudhry K, Nadayil D, et al. (2009). Changing trends in incidence of breast cancer: Indian scenario. Ind J Cancer 46: 73-74.

Pasalich M, Su D, Binns CW, Lee AH (2013). Reproductive factors for ovarian cancer in southern Chinese women. J Gynecol Oncol 24:135- 140.

Murthy NS, Shalini S, Sastry NB, Suman G, Sreekantaiah P, Mathew A (2011). Increase in incidence of cancer of corpus uteri: estimation of time trends - an Indian scenario. Eur J Cancer Prev 20:25-32.

C r a m e r D W ( 2 0 1 2 ) . T h e epidemiology of endometrial and ovarian cancer. Hematol Oncol Clin North Am 26:1-12.

Kuriki K, Tajima K (2006). The increasing incidence of colorectal cancer and the preventive strategy in Japan. Asian Pac J Cancer Prev 7: 495–501.

Plesko I, Boyle GS, Ondrusova M, Tomasek L, Kubik A ( 2008). Dominant position of colorectal cancer in Slovakia: the old-new problem for cancer control. Neoplasma 55:10–15.

Center MM, Jemal A, Ward E (2009). International trends in colorectal cancer incidence rates. Epidemiol Biomarkers Prev 18(6):1688–1694.

Yeole BB (2008). Trends in Cancer Incidence in Esophagus, Stomach, Colon, Rectum and Liver in Males in India. Asian Pacific J Cancer Prev 9: 97-100.

N o o y i S C , M u r t h y N S , Shivananjaiah S, Sreekantaiah P, Mathew A (2011). Trends in Rectal Cancer Incidence - Indian Scenario. Asian Pacific J Cancer Prev 12:2001-2006.

Siegel R , Ward E, Brawley O, Jemal A (2011).The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61(4):212-236.

Patel JD (2005). Lung cancer in women. J Clin Oncol 23 : 3212 – 3218.


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