Biomedical Applications of Nanomaterials: Diagnosis and Therapy of Thrombotic Disorders

D Dash

Abstract


We have employed unique properties of carbon-based as well as metallic nanomaterials to develop diagnostic / therapeutic devices targeted against thrombotic disorders. We have designed a novel graphene-based biosensor that can detect individuals with high coronary risk. Further, we describe an innovative strategy to ablate pathological thrombus in situ employing near-infrared laser-irradiated gold nanorods (photothermal therapy).

Keywords: Thrombus, biosensor, photothermal therapy, platelet-derived microparticles.

 


Keywords


Thrombus, biosensor, photothermal therapy, platelet-derived microparticles.

Full Text:

PDF

References


van der Zee PM, Biro E, Ko Y, et al (2006). P-selectin- and CD63-exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction. Clin Chem 52: 657-664.

Ueba T, Nomura S, Inami N, et al (2010). Plasma level of platelet- derived microparticles is associated with coronary heart disease risk score in healthy men. J Atheroscler Thromb 17: 342-349.

Siljander PR (2011). Platelet-derived microparticles - an updated perspective. Thromb Res 127 (Suppl 2):S30-S33.

Higgins IJ, Lowe CR (1987). Introduction to the principles and applications of biosensors. Philos Trans R Soc Lond B Biol Sci 316: 3-11.

Lvovich V, Srikanthan S, Silverstein RL (2010). A novel broadband impedance method for detection of cell-derived microparticles. Biosens Bioelectron 26: 444-451.

Kailashiya J, Singh N, Singh SK, Agrawal V, Dash D (2015). Graphene oxide-based biosensor for detection of platelet-derived microparticles: a potential tool for thrombus risk identification. Biosens Bioelectron 65: 274-280.

Patent No. 1959/DEL/2013, dated 02.07.2013.

Tsai MF, Chang SH Gilbert, Cheng FY, et al (2013). Au nanorod design as light- absorber in the first and second biological near-infrared windows for in vivo photothermal therapy. ACS Nano 7: 5330–5342.

Singh N, Varma A, Verma A, Maurya BN, Dash D (2016). Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective. Nano Res 9: 2327-2337.

Patent No. 3168/DEL/2014, dated 03.11.2014.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.